急诊PCI术后MDA水平的动态变化及依达拉奉对其的影响

[目的]探讨急诊PCI术后脂质过氧化产物丙二醛(MDA)的动态变化规律及依达拉奉对其的影响。[方法]56例初发AMI患者被随机分为对照组与干预组,干预组入院时即给予依达拉奉静滴,疗程7d。检测术前即刻、术后1、6、12、24、48h、7d血浆丙二醛(MDA)水平,同时检测血浆CK-MB峰值浓度,发病d7行超声心动图评价左室功能,观察两组术后心肌缺血再灌注损伤临床事件与不良反应。[结果]急诊PCI再灌注治疗后对照组各时点MDA均较术前显著升高,再灌注后1h达峰值,而后逐渐下降,d7时仍高于术前水平,干预组术后各时点MDA水平均较对照组显著降低,差异有统计学意义(P﹤0.05);干预组心肌缺血再灌注损伤临床事件发生率及CK-MB峰值浓度较对照组明显降低,左室功能指标明显优于对照组,差异有统计学意义(P﹤0.05),两组均未见不良反应。[结论]AMI患者急诊PCI术后血浆脂质过氧化标志物丙二醛显著升高,依达拉奉能减轻其升高水平,减轻心肌缺血再灌注损伤。

THE DYNAMIC CHANGES OF MALONALDCHYDE AFTER EMERGENT PERCUTANEOUS CORONARY INTERVENTION AND THE EFFECT OF EDARAVONE ON IT

[Objective]To investigate the dynamic changes of Malonaldchyde(MDA)after emergent percutaneous coronary intervention(EPCI)and the effects of Edaravone on it.[Methods]Fifty-six patients with initial AMI patients were randomly assigned to receive 30mg edaravone or a placebo intravenously just before and after reperfusion,with 7 days in a course.The serum MDA concentration just before reperfusion and different time point(1,6,12,24,48 hour and 7 day)after reperfusion were detected.The serum CK-MB concentration ...