| 大剂量沐舒坦治疗小儿急性肺损伤 |
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| 引用本文： | 刘秀清,李宏伟.大剂量沐舒坦治疗小儿急性肺损伤[J].现代预防医学,2011,38(20):4142-4143,4145. |
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| 作者姓名： | 刘秀清 李宏伟 |
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| 作者单位： | 河北省唐山市开平医院儿科,唐山,063021 |
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| 摘 要： | 目的]结合临床实践经验,探讨大剂量沐舒坦治疗小儿急性肺损伤的临床疗效。方法]采用对照研究法,将患儿随机分为3组,分别为对照组(44例)、常规剂量组(44例)和大剂量组(44例),3组采用不同的治疗方法,通过对比分析,探讨大剂量沐舒坦治疗小儿急性肺损伤的临床疗效。采用Microsoft Excel建立数据库,运用SPSS13.0统计软件进行统计分析。所有计量资料用(均数±标准差)表示,采用t检验以及χ2检验,取P﹤0.05为差异有统计学意义。结果]治疗前,3组间PaO2及PaO2/FiO2差异无统计学意义。治疗后PaO2及PaO2/FiO2较治疗前明显好转,治疗3d后,大剂量组PaO2及PaO2/FiO2明显高于对照组和常规剂量组,差异有统计学意义(P﹤0.05)。对照组、常规剂量组和大剂量组经治疗进展到ARDS者分别有10、8、2例,组间比较有差异有统计学意义,其中分别有6、5和1例死亡,死亡率各组间差异无统计学意义。剔除ARDS病例后,大剂量组PaO2/FiO2恢复到300mmHg以上时间明显短于常规剂量组和对照组,差异有统计学意义(P﹤0.05),而常规剂量组和对照组间对方差异无统计学意义(P﹥0.05)。结论]沐舒坦对小儿ALI患者肺功能有明显的保护作用,应用大剂量沐舒坦对小儿ALI的预防、治疗和转归具有良好的疗效,值得临床推广应用。
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| 关 键 词： | 大剂量沐舒坦 小儿急性肺损伤 急性呼吸窘迫综合征 |
HIGH DOSE AMBROXOL IN TREATMENT OF CHILDREN WITH ACUTE LUNG INJURY |
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| LIU Xiu-qing,LI Hong-wei.HIGH DOSE AMBROXOL IN TREATMENT OF CHILDREN WITH ACUTE LUNG INJURY[J].Modern Preventive Medicine,2011,38(20):4142-4143,4145. |
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| Authors: | LIU Xiu-qing LI Hong-wei |
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| Institution: | LIU Xiu-qing,LI Hong-wei.(Pediatric Hospital of Kaiping in Tangshan,Tangshan 063021,China) |
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| Abstract: | Objective]With clinical practice experience,we explored the high dose ambroxol in treatment of children with clinical acute lung injury.Methods]A control study,the children were randomly divided into 3 groups as control group(44 cases),the conventional dose group(44 cases)and high dose group(44 cases). The three different treatment methods were compared to explore the clinic effect of high dose ambroxol clinical in treatment of children with acute lung injury. We established a database using Microsoft Exc... |
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| Keywords: | High dose ambroxol Acute lung injury Acute respiratory distress syndrome in children |
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