10d序贯疗法与传统三联疗法对Hp阳性消化性比较

目的]比较含左旋氧氟沙星的10d序贯疗法与传统三联疗法对Hp阳性的消化性溃疡患者的疗效。方法]将89例Hp阳性的患者随机分为两组,观察组45例前5d给予奥关拉唑40mg+阿莫西林l.09,后5d给予奥美拉唑40mg+左氧氟沙星0.49+克拉霉素0.59,对照组44例给予奥关拉唑40mg+克拉霉素0.59+阿莫西林1.09,完成治疗后28d和6个月复查胃镜及Hp检测。结果]观察组Hp清除率为93.0%,溃疡愈合率为81.4%,远高于对照组的79.6%和61.2%(P﹤0.05);观察组溃疡复发率为12.5%,低于对照组的33.3%(P﹤0.05)。结论]含左旋氧氟沙星的10d序贯疗法对Hp阳性的消化性溃疡的疗效优于传统三联疗法,近期复发率较低。

COMPARISON OF THE EFFICACY OF TEN-DAY SEQUENTIAL THERAPY AND CONVENTIONAL TRIPLE THERAPY FOR HELICOBACTER PYLORI ERADICATION

Objective]To compare the efficacy of ten-day sequential therapy and conventional triple therapy for Helicobacter pylori eradication.Methods]89 patients with proven Helicobacter pylori infection received ten-day sequential therapy(40 mg of Omeprazole,and 1g of amoxicillin for the first 5 days,followed by 40 mg of Omeprazole,40 mg of Levofloxacin and 500 mg of clarithromycin).In controls,44 patients received conventional triple therapy(40 mg of Omeprazole,500mg Clarithromycin and 1g amoxicillin).Results]Er...