| 谷胱甘肽产生菌的菌种选育 |
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| 引用本文： | 陈雪,赵文杰,冯军,程晴华,薛春佳. 谷胱甘肽产生菌的菌种选育[J]. 中国医药工业杂志, 2007, 38(7): 481-483 |
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| 作者姓名： | 陈雪 赵文杰 冯军 程晴华 薛春佳 |
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| 作者单位： | 上海医药工业研究院,上海,200040 |
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| 摘 要： | 采用紫外线和亚硝基胍对出发菌株SIPI-G0619进行诱变,同时使用乙硫氨酸、氯化锌和三氮唑三种抗性筛选物为筛选模型,最终筛选得到稳定的谷胱甘肽高产菌株SIPI-Gh435;谷胱甘肽产量为864mg/L,是出发菌株的4.9倍。
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| 关 键 词： | 假丝酵母 谷胱甘肽 菌种选育 |
| 文章编号： | 1001-8255（2007）07-0481-03 |
| 修稿时间： | 2006-11-14 |
Breeding of Glutathione-Overproducing Strain |
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| CHEN Xue,ZHAO Wen-jie,FENG Jun,CHENG Qing-hua,XUE Chun-jia. Breeding of Glutathione-Overproducing Strain[J]. , 2007, 38(7): 481-483 |
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| Authors: | CHEN Xue ZHAO Wen-jie FENG Jun CHENG Qing-hua XUE Chun-jia |
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| Affiliation: | Shanghai Institute of Pharmaceutical Industry, Shanghai 200040 |
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| Abstract: | Candida utilis SIPI-G0619 was mutagenized by ultraviolet radiation and NTG treatment. A new mutant strain SIPI-Gh435 was finally isolated under the coaction of ethionine, zinc chloride and 1,2,4-triazole. The yield of intracellular glutathione in SIPI-Gh435 was 864mg/L, which was 4.9 times higher than the original strain. |
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| Keywords: | Candida utilis glutathione strain breeding |
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