苦参对急性白血病患者sICAM-1和sVCAM-1水平的影响

目的探讨苦参对急性白血病患者可溶性细胞间黏附分子-1(sICAM-1)和可溶性血管细胞黏附分子-1(sVCAM-1)水平的影响。方法选取2013年3月至2015年3月该院收治的急性白血病患者60例,按照治疗方式的不同将患者分为常规化疗组和苦参治疗组,每组各30例。常规化疗组患者给予常规化疗方案实施治疗,苦参治疗组患者在常规化疗基础上加用苦参治疗。另选取同期该院健康体检者60例作为健康对照组。采用酶联免疫吸附试验(ELISA)分析急性白血病患者治疗前后和健康体检者血清sICAM-1、sVCAM-1水平。结果急性白血病患者血清sICAM-1、sVCAM-1水平在治疗前及治疗后均明显高于健康对照组,两者比较差异有统计学意义(P0.05)。常规化疗组及苦参治疗组,治疗后患者血清sICAM-1、sVCAM-1水平均有下降,苦参治疗组sICAM-1、sVCAM-1的水平下降程度较常规化疗组更明显,差异有统计学意义(P0.05)。苦参治疗组治疗有效率为90.00%,高于常规化疗组的67.67%,差异有统计学意义(P0.05)。结论苦参可明显降低急性白血病患者血清sICAM-1、sVCAM-1水平,改善常规化疗药物疗效,促进患者康复。

Effects of radix sophorae flavescentis on serum levels of sICAM-1 and sVCAM-1 in patients with acute leukemia

Objective To investigate the effect of radix sophorae flavescentis on the levels of soluble intercellu-lar adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1(sVCAM-1) in the patients with a-cute leukemia .Methods 60 cases of acute leukemia in our hospital from March 2013 to March 2015 were selected and divided into the conventional chemotherapy group and the radix sophorae flavescentis therapy group according to dif-ferent therapeutic methods ,30 cases in each group .The conventional chemotherapy group was given the routine chemotherapy regimen for implementing the therapy ,while on this basis the radix sophorae flavescentis therapy group was added with radix sophorae flavescentis .Contemporaneous 60 individuals undergoing the healthy physical exami-nation were selected as the healthy control group .The levels of serum sICAM-1 and sVCAM-1 before and after treat-ment in the patients with acute leukemia and the healthy individuals of physical examinations were detected by using ELISA .Results The serum sICAM-1 ,sVCAM-1 levels before and after treatment in the patients with acute leuke-mia were significantly higher than those in the healthy control group ,the difference was statistically significant (P<0 .05) .The serum sICAM-1 and sVCAM-1 levels in the conventional chemotherapy group and the radix sophorae fla-vescentis therapy group were decreased after treastment ,but the decrease degree in the radix sophorae flavescentis therapy group was more significant compared with the conventional chemotherapy group ,the difference was statisti-cally significant(P<0 .05) .The effective rate in the radix sophorae flavescentis therapy group was 90 .00% ,which was significantly higher than 67 .67% in the conventional chemotherapy group ,the difference was statistically signifi-cant (P<0 .05) .Conclusion Radix sophorae flavescentis can obviously reduce the serum sICAM-1 and sVCAM-1 levels ,improves the curative effect of conventional chemotherapy drugs and promotes the recovery in the patients w ith acute leukemia .