127例CRP和SAA检测结果不一致病例分析

目的分析127例血清淀粉样蛋白A(SAA)和C-反应蛋白(CRP)检测结果不一致病例。方法选择127例SAA增高而CRP正常及CRP增高而SAA正常的患者,分别对白细胞计数(WBC)、中性粒细胞比例(NEU%)、CRP和SAA四个指标进行检测及相关性分析。结果 SAA增高而CRP正常的118例患者中,WBC9.5×10~9/L(A组)的SAA与CRP呈明显正相关(r=0.482,P0.01);WBC在(3.5~9.5)×10~9/L(B组)的SAA与CRP呈明显正相关(r=0.267,P0.05),SAA与NEU%呈明显正相关(r=0.334,P0.01);WBC3.5×10~9/L(C组)的WBC、CRP和SAA三项之间均无相关性,但WBC与NEU%呈明显正相关(r=0.503,P0.05);CRP增高而SAA正常的9例患者中,SAA与CRP呈正相关(r=0.842,P0.01)。结论临床上进行感染性疾病的快速诊断时,四个指标中任何一项均应认真结合临床做出判断,以免漏诊或误诊。

Analysis on inconformity of SAA and CRP detection results in 127 cases

Objective To analyze the inconformity of serum amyloid protein A (SAA) and C reactive protein (CRP) detection results in 127 cases .Methods 127 cases of increased SAA with normal CRP and increased CRP with normal SAA were selected ,and their WBC ,NEU% ,CRP and SAA were detected .The correlation of these four indexes was analyzed at the same time .Results Among 118 cases of increased SAA with normal CRP ,there was sig-nificant correlation between SAA with CRP in the WBC>9 .5 × 109/L group(group A)(r=0 .482 ,P<0 .01) ,signifi-cant correlation between SAA with CRP and significant correlation between SAA with NEU% in the WBC(3 .5 -9 .5)× 109/L group( group B)(r=0 .267 ,P<0 .05 ;r=0 .334 ,P<0 .01);WBC ,CRP and SAA were uncorrelated with each other in the WBC<3 .5 × 109/L group(group C) ,while WBC had significant correlation with NEU% (r=0 .503 ,P<0 .05) .In 9 cases of increased CRP with normal SAA ,there was significant correlation between SAA with CRP(r=0 .842 ,P<0 .01) .Conclusion In clinical rapid diagnosis of infectious diseases ,any one item of these four in-dexes should be judged by carefully combining with clinic for avoiding missed diagnosis or misdiagnosis of infectious diseases .