Prostaglandin E1-initiated immune regulation during human mixed lymphocyte reaction |
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Authors: | Takahashi Hideo K Xue Dong Iwagaki Hiromi Tamura Ryuji Katsuno Goutarou Yagi Takahito Yoshino Tadashi Mori Shuji Nishibori Masahiro Tanaka Noriaki |
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Institution: | Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama City 700-8558, Japan. |
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Abstract: | Prostaglandin E1 (PGE1) has therapeutic value for transplantations due to its microvascular activity. Interleukin (IL)-18, which is elevated in plasma during the acute rejection after organ transplantation, elicits the expression of intercellular adhesion molecule (ICAM)-1, B7.1, B7.2, CD40, and CD40 ligand (CD40L) on monocytes as well as the production of interferon (IFN)-gamma and IL-12 and proliferation of T-cells during the human mixed lymphocyte reaction (MLR) in an in vitro model of acute rejection. In contrast, PGE1 inhibits all the adhesion molecule expression, cytokine production and T-cell proliferation in the presence of IL-18. The effects of PGE1 depend on stimulation of the IP/EP2/EP4-receptor, and thus, PGE1 might have therapeutic potential for treating acute rejection due to its immune regulatory effect. |
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Keywords: | IL-18 Human MLR Adhesion molecule Prostaglandin |
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