肝素钠软膏对多巴胺诱发兔静脉及其周围组织损伤治疗的实验研究

目的：笔者观察了肝素钠软膏、５０％硫酸镁、透明质酸酶对多巴胺诱发兔静脉及其周围组织损伤的治疗作用。方法：兔耳静脉连续注身大剂量的多巴胺和静脉周围组织注射多巴胺诱发静脉炎。结果：５０％硫酸镁加肝素钠软膏对多巴胺诱发的静脉炎治疗效果最好，其次为肝素钠软膏和５０％硫酸镁，透明质酸酶无治疗作用。

An experimental study of the therapeutical effects of sodium heaprinate ointment on dopamine induced damage of the rat veins and peripheral tissues

Objective:To observe the therapeutical effects of sodium heparinate ointment, 50% magnesium sulfate and hyaluronidase on dopamine induced damage of the rat vein and the tissues around it. Methods:Vasculitis was induced by continuous injection of large dose of dopamine into the rat ear vein and tissues around it. 50% magnesium sulfate and sodium heparinate ointment were topically used in separation and combination respectively in the lesion, and hyaluronidase was injected subctaneously into the lesion. Results:The best result was obtained by the use of 50% magnesium sulfate in combination with sodium heparinate ointment, the separate use of 50% magnesium sulfate and sodium heparinate ointment got the second, and the use of hyaluronidase got no effect. Conclusion:The use of 50% magnesium sulfate and sodium heparinate ointment had good effect in treating vasculiis induced by drug extravasation.