急性白血病患者MRP、p170与多药耐药关系的分析

目的：评价ｐ糖蛋白（ｐ１７０）和多药耐药相关蛋白（ｍｕｌｔｉｄｒｕｇ ｒｓｓｉｔａｎｃｅ－ａｓｓｏｃｉａｔｅｄ ｐｒｏｔｅｉｎ，ＭＲＰ）表达与急性白血病患者多药耐药的关系。方法：将急性白血病患者按治疗效果分为初治敏感组、完全缓解组和复发难治组三组，用免疫细胞化学结合流式细胞仪测定ｐ１７０和ＭＲＰ。结果：ｐ１７０在各型白血病中完全缓解组均低于初治和复发难治组，ＭＲＰ在ＡＭＬ中复发难治组明显高于完全缓

The relationship between MRP, p170 expression and MDR in acute leukemia

Objective:To evaluate the relationship between MRP, p170 expression and MDR in acute leukemia patients. Methods:83 patients were divided into three groups: untreated (A), complete remission (B) and relapsed/refractory (C), detected their MRP and p170 expression by immunocytochemistry and FACS. Results: p170 expression was lower in B group than in A and C groups in AML and ALL, MRP expression in AML was higher in C group than in B group; there were 27 of 35 patients expressed one or two proteins in C group; The combination of p170 and MRP detection turned out to be a more sensitive, speculiar and accurate way in evaluation of MDR. Conclusion:clinical MDR is multifactorial, p170 and MRP are all associatd with it.