碱性成纤维细胞生长因子及成纤维细胞生长因子受体在豚鼠前庭中的定位和表达

目的 :观察碱性成纤维细胞生长因子 ( b FGF)及成纤维细胞生长因子受体 ( FGFR)在豚鼠前庭终器的定位和表达。方法 :免疫组织化学。结果 :b FGF位于支持细胞和毛细胞的胞浆及胞核 ,FGFR位于支持细胞表面。b FGF及 FGFR在成年豚鼠表达较弱 ,新生豚鼠及庆大霉素内耳损伤豚鼠表达较强。结论 :提示 b FGF在豚鼠前庭终器发育、结构功能维持及损害后修复中起重要作用

Location and expression of basic fibroblast growth factor and fibroblast growth factor receptor on vestibular organs of guinea pigs

Objective:To examine the location and expression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor (FGFR) on vestibular organs of guinea pigs. Methods:Immunohistochemistry. Results:bFGF was in the plasma and nuclear of supporting and hair cells; FGFR was on the surface of supporting cells. Weak bFGF and FGFR immunoreactivity was detectable in normal adults. Strong bFGF and FGFR immunoreactivity was detectable in the neonatal and adults whose inner ears were destroyed by gentamicin. Conclusion:bFGF may have a role in the development of vestibular organs and in maintenance of the integrity of structure and function of vestibular organs, and in protection and repair processes following damage to the vestibular organs.