| 急性肾功能衰竭与内皮素-1关系的电镜免疫组化观察 |
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| 引用本文： | 王晓虹,梁延杰,陆江阳,李玲,杨毅.急性肾功能衰竭与内皮素-1关系的电镜免疫组化观察[J].军医进修学院学报,2000,21(1):36-38. |
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| 作者姓名： | 王晓虹 梁延杰 陆江阳 李玲 杨毅 |
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| 作者单位： | 解放军304医院病理智科,北京,100037 |
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| 基金项目： | “八五”军队科研基金!项目 ( 91Z0 0 5 ) |
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| 摘 要： | 目的：探讨ＥＴ－１在ＡＲＦ发病机制中的作用。方法：甘油肌注法复制成大鼠ＡＲＦ模型，免疫电镜技术动态观察ＥＴ－１在超微水平的分布与变化。结果：ＡＲＦ大鼠肾小管上皮及其线粒体中ＥＴ－１含量明显增加，且与肾组织病变程度呈正相关。结论：肾小管上皮细胞中ＥＴ－１持续增多是导致肾小管坏死的重要原因，提示ＥＴ－１与ＡＲＦ发病机制中有重要联系。
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| 关 键 词： | 急性肾功能衰竭 内皮素－1 免疫组织化学 |
Observation of immunohistochemistry and immunoelectron-microscopy of ET-1 in acute renal failure |
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| WANG Xiao-hong,LIANG Yan-jie,LU Jiang-yang,LI Ling,YANG Yi.Observation of immunohistochemistry and immunoelectron-microscopy of ET-1 in acute renal failure[J].Academic Journal of Pla Postgraduate Medical School,2000,21(1):36-38. |
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| Authors: | WANG Xiao-hong LIANG Yan-jie LU Jiang-yang LI Ling YANG Yi |
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| Abstract: | Objective:To explore the effects of Endothelin 1 (ET 1) on acute renal failure (ARF). Methods:A model of ARF was done by injecting glycerol into the muscle of Wistar rats. We utilized immnohistochemistry and immunoelectronmicroscopy method at ultrastructure level in observation of the distribution and content of ET 1 in kidney of ARF rats. Results:ET 1 content in ARF rats was increased, most of ET 1 particles were distributed with plasma and mitochondria of renal tubular epithelial cells and at same time there were serious pathology changes. Conclusion:The maintain increase of ET 1 content is an important cause of renal tubular necrosis in ARF. It is suggested that ET 1 take part in the mechanism of ARF. |
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| Keywords: | acute renal failure immunoelectronmicroscopy endothelin 1 |
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