结石对胆囊粘膜病理损害与胆囊癌关系的研究

研究１２０例结石性慢性胆囊炎，７５例无结石慢性胆囊炎及２４例胆囊癌的胆囊标本，结果显示结石组中胆囊粘膜的非典型增生病变的发生率为２５．８％，无结石组中发生率为２．７％，两组判别有极显著性意义（Ｘ＾２＝１７．６０，Ｐ〈０．０１）。说明结石的存在加重胆囊粘膜的病理损害。对各组胆囊粘膜细胞核ＤＮＡ含量及ＡｇＮＯＲ颗粒计数进行研究，发现单纯增生、轻、中、重非典型增生，高、中、低分化胆囊癌，其ＤＮＡ含量及Ａ

The pathologic lesions in gallbladder mucosa caused by stone and the relations between gallstone and gallbladder cnacer

We studied 120 cases of chronic calculous cholecystitis,75 cases of chronic cholecystitis without stone and 24 cases of gallblabber cancer.Dysplasia lesions in gallbladder mucosa were found at rates of 25 8% and 2 75% in cases of cholecystitis with and without stone.The difference was significant(X 2=18 26,P<0 01).Then we studied the DNA and AgNOR contents of gallbladder mucosa cells in all groups.It was found that the contents of DNA and AgNOR increased gradually from hyperlasia dysplasia to cancer,and there was a significant difference between any two groups.The result revealed the cell dynamic changes of gallbladder mucosa from the benign lesion to the malignant lesion.It was concluded that the gallstone exacerbated the pathologic lesions and promoted the occurrence of gallbladder cancer.The cholrcystrctomy was recommended in the patients with gallstone.