53例IgA肾病临床相关研究

目的：分析血清IgA对IgA肾病（IgAN）发生发展的影响，探讨影响kAN预后的病理和临床因素。方法：分析53例IgAN患者血清IgA以及Katafuchi积分、24小时尿蛋白、年龄及高血压等对IgAN发生发展及预后的影响。结果：①IgAN组血清IgA明显高于非IgAN组及对照组，病理损害较重的Ⅳ-V级组血清IgA明显高于病理损害较轻的I-Ⅲ级组；②与病理损害较轻的I-Ⅲ级组相比，病理损害较重的Ⅳ-V级组Katafuchi积分、24小时尿蛋白、年龄及高血压均明显增高。结论：IgAN是一种免疫复合物性肾小球肾炎，血清IgA的升高对IgAN的诊断及判断病情严重程度有一定的意义。Katafuchi积分能较满意地判断IgAN的病情严重程度。年龄、高血压、持续性蛋白尿是IgAN进展的危险因素．

Clinical Trial on 53 IgA Nephropathy Patients

Objective： to study the effects of serum IgA on the occurrence and progression of IgA nephropathy （IgAN）, and to explore clinical and pathological factors for the prognosis of IgAN. Methods： To investigate the effects of serum IgA, Katafuchi Score, 24-hour urine protein, age and hypertension on the occurrence, progression and prognosis of IgAN in 53 patients. Results： 1. Serum IgA in the IgAN group was significantly higher than that in both non-IgAN grouo and control zrouo： 2. Serum IgA, Katafuchi Score, 24-hour urine protein, age and blood pressure in the IV-V group with relatively severe pathological damage were significantly higher than those in the I-III group with relatively moderate pathological damage.