| 芍药甘草汤提取物(芍甘多苷)对实验性肝损伤的影响 |
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| 引用本文： | 宋军,王晓东,赵军宁,戴瑛,邓治文.芍药甘草汤提取物(芍甘多苷)对实验性肝损伤的影响[J].中药药理与临床,2010(2). |
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| 作者姓名： | 宋军 王晓东 赵军宁 戴瑛 邓治文 |
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| 作者单位： | 四川省中医药科学院药理毒理研究所;国家中医药管理局中药质量生物学评价重点研究室; |
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| 基金项目： | 国家十五科技攻关计划项目(2001BA701A07-22); 四川省重大科技招标项目(编号:01SG003-33) |
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| 摘 要： | 目的:探讨芍甘多苷(DSM)对多种实验性肝损伤的保护作用。方法:分别采用四氯化碳(CCl4)、D-氨基半乳糖(D-GalN)诱发小鼠化学性急性肝损伤,内毒素+卡介苗(LPS+BCG)诱发小鼠免疫性肝损伤,然后灌胃给予不同剂量的DSM,每天1次,连续4天,观察药物对血清转氨酶和肝脏病理形态的影响。结果:模型组小鼠血清转氨酶及肝脏病理组织学评分明显增高,DSM组血清转氨酶,肝脏病理组织学评分有不同程度的降低。结论:DSM能减轻化学性和免疫性肝损伤,具有明显的保肝作用。
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| 关 键 词： | 芍药甘草汤 芍甘多苷 急性肝损伤 肝脏保护 |
Influence on experimental liver injury of extraction from Peony and Licorice Decoction |
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| Song Jun,Wang Xiaodong,Zhao Junning,Dai Ying,Deng Zhiwen.Influence on experimental liver injury of extraction from Peony and Licorice Decoction[J].Pharmacology and Clinics of Chinese Materia Medica,2010(2). |
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| Authors: | Song Jun Wang Xiaodong Zhao Junning Dai Ying Deng Zhiwen |
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| Institution: | Song Jun,Wang Xiaodong,Zhao Junning,Dai Ying,Deng Zhiwen (Institute of Pharmacology , Toxicology,Sichuan Academy of TCM Sciences,Chengdu 610041) |
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| Abstract: | Objective:To investigate protective effect of shaogan polyglycosides on murine experimental liver injury. Methods:Mices with acute liver injury induced by CCl4 and D-GalN,with immunological liver injury induced by LPS+BCG are given different doses of shaogan polyglycosides(DSM),then observation serum transaminases and pathologic morphology of liver. Results:DSM can reduce serum transaminases and improve pathological changes of mices with all kinds of liver injury. Conclusions:DSM can alleviate chemical and ... |
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| Keywords: | Peony and licorice decoction acute liver injure liver protection |
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