Inhibitory activity of monoamine oxidase by coumarins fromPeucedanum japonicum |
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Authors: | Dang Thi Lan Huong Hee Cheol Choi Tae Cheol Rho Hyun Sun Lee Myung Koo Lee Young Ho Kim |
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Affiliation: | College of Pharmacy, Chungnam National University, Taejon, Korea. |
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Abstract: | Four coumarins were isolated from chloroform extract of the root of Peucedanum japonicum and identified as praeruptorin A(1), xanthotoxin (2), psoralen (3) and bergapten (4) on the basis of spectroscopic methods. The inhibitory activities of these coumarins on monoamine oxidase prepared by mouse brain were tested. The IC50 values of them were shown to be 27.4 microM (1), 40.7 microM (2), 35.8 microM (3), and 13.8 microM (4), in vitro. |
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Keywords: | Peucedanum japonicum Umbelliferae Coumarins Monoamine oxidase |
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