| CyclinD_1在多形性腺瘤和多形性腺癌中的表达 |
| |
| 引用本文： | 伍虹,黄洪章,王建广.CyclinD_1在多形性腺瘤和多形性腺癌中的表达[J].口腔颌面外科杂志,2002,12(3):198-201. |
| |
| 作者姓名： | 伍虹 黄洪章 王建广 |
| |
| 作者单位： | 中山大学附属孙逸仙纪念医院口腔颌面外科,510120 |
| |
| 摘 要： | 目的 研究cyclinD1 在正常腮腺、多形性腺瘤 (PA)和多形性腺瘤癌变 (CPA)中的表达特点、表达水平及其与临床指标的关系。方法 应用免疫组化S P法检测cyclinD1 在 1 0例正常腮腺、37例PA和 1 4例CPA标本中的表达 ,图像分析cyclinD1 的表达水平。统计方法 :χ2 检验、ANOVA检验和t检验。结果 在CPA中cyclinD1 的表达以 ～ 为主 ,阳性率 78 6 % ,PA组中多为 -和 +,cyclinD1 在正常腮腺中表达与PA、CPA组差别显著 (P <0 0 5) ,CPA中cyclinD1 的表达水平也显著高于PA组 (P <0 0 5)。结论 cyclinD1 的异常表达在CPA的发生中起到重要的作用。
|
| 关 键 词： | CyclinD_1 腮腺肿瘤 |
| 文章编号： | 1005-4979(2002)03-0198-04 |
| 修稿时间： | 2001年8月21日 |
THE EXPRESSION OF CYCLIN D1 IN PLEOMORPHIC ADENOMA AND IN PLEOMORPHIC CARCINOMA OF PAROTID GLAND |
| |
| WU Hong,?HUANG Hong zhang,?WANG Jiang guang.THE EXPRESSION OF CYCLIN D1 IN PLEOMORPHIC ADENOMA AND IN PLEOMORPHIC CARCINOMA OF PAROTID GLAND[J].Chinese Journal of Oral and Maxillofacial Surgery,2002,12(3):198-201. |
| |
| Authors: | WU Hong ?HUANG Hong zhang ?WANG Jiang guang |
| |
| Abstract: | Objective To study the expression character and level of cyclin D 1 in normal parotid gland, PA and CPA; the correlation between the expression and the clinical factors. Methods We used the S P Immunohistochemistry to detect the expression of cyclin D 1 in 10 normal parotids, 19 PA cases and 14 CPA cases. Results The positive rate of cyclin D 1 expression was 78 6% in CPA, the expression was ～. But cyclin D 1 expressed — or + in most of PA. The positive rate in normal parotid was significantly lower than that in PA and CPA ( P <0 05). The expression level of cyclin D 1 in CPA was obviously higher than that in PA ( P <0 05). Conclusion The abnormal expression of cyclin D 1 may play an important role in the tumorigenesis of CPA. |
| |
| Keywords: | Cyclin D 1 Parotid neoplasms |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
