B型利钠肽和左室舒张功能障碍关系的研究

目的 探讨眼底荧光造影（FFA）及血清转化生长因子β1（TGFβ1）检测对糖尿病肾病（DN）早期诊断的作用。方法87例糖尿病（DM）患者依据FFA分为：DM组：无糖尿病视网膜病变组；DR组：有糖尿病视网膜病变非增殖期组；C组：健康对照组。DR组依据糖尿病视网膜病变（糖网）分期分成DRl组、DR2组和DR3组；再将DR组依据尿蛋白排泄率（UAER）分为：DRA组：UAER〈20μg／min；DRB组：UAER〉20μg／min。各组测血清TCFβ1。结果 （1）UAER：DR组高于DM组，并随糖网进展而升高，差异有统计学意义（P〈0.001）。（2）TGFβ1：DR组高于DM组和C组，DRA组低于DRB组；DR1组低于DR2组和DR3组，差异均有统计学意义（P〈0．05）。结论糖尿病患者FFA异常早于UAER升高。TCFβ1在Ⅰ期糖网已升高，并随糖网及DN的加重而升高。UAER随糖网进展而升高。FFA与TCFβ1可能是DN发生发展的重要指标。

Relation of B-type natriuretic peptide and left ventricular diastolic function

Objective To explore the change and implication of plasma B-type natriuretic peptide (BNP)level in patients with asymptomatic and asymptomatic symptomatic left ventricular (LV) diastolic dysfunction. Methods Twenty normal controls and 60 patients referred for echocardiography to evaluate the presence LV dysfunction. Patients with abnormal systolic function were excluded. Patients were classified as asymptomatic LV diastolic dysfunction group and minimally symptomatic LV diastolic dysfunction group. The plasma BNP concentrations was determined by solid - phase immunoradiometric assay. Results Asymptomatic LV diastolic dysfunction group and symptomatic LV diastolic dysfunction group had higher BNP level than normal controls (P<0.01). Patients with symptomatic diastolic dysfunction had higher BNP level than those patients with asymptomatic diastolic dysfunction (P <0.01). Conclusions BNP elevated makes an useful indicator for LV diastolic function.