Neoplastic meningitis from breast carcinoma with complete response to liposomal cytarabine: case report |
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Authors: | Paola Gaviani A Silvani E Corsini A Erbetta A Salmaggi |
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Institution: | (1) Neuro Oncology Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy;(2) Laboratory of Clinical Analyses, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy;(3) Neuroradiology Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy |
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Abstract: | Neoplastic meningitis from breast cancer often leads to a progressive neurologic deterioration followed by fatal outcome. The therapy is based on the administration of high dose systemic chemotherapy with drugs able to pass through the blood-brain barrier, such as methotrexate (MTX) and cytarabine, cranial or craniospinal irradiation, and intrathecal (IT) administration of MTX and/or cytarabine. However, these approaches only have modest efficacy and are associated with side effects for the patients. A depot formulation of liposomal cytarabine (DepoCyte®) has proven to be useful in clinical trials. We describe the case of a woman with a diagnosis of leptomeningeal carcinomatosis from breast carcinoma who presented cerebrospinal fluid normalization and prolonged complete MRI response to intrathecal chemotherapy with liposomal cytarabine (DepoCyte). |
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Keywords: | Neoplastic meningitis Breast carcinoma Chemotherapy Liposomal cytarabine |
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