Polysaccharide gene transfection agents |
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| Authors: | Wahid Khan Hossein Hosseinkhani Diana Ickowicz Po-Da Hong Da-Shyong Yu Abraham J Domb |
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| Institution: | 2. Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology (TAIWAN TECH), Taipei 10607, Taiwan;3. Nanomedicine Research Center, National Defense Medical Center, Taipei 10607, Taiwan;1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry and Physics of the Ministry of Education, Center for Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;2. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China;3. University of Chinese Academy of Sciences, Beijing 100049, China;4. Department of Civil, Chemical, Environmental, and Materials Engineering, University of Bologna, Via Terracini 28, 40131, Bologna, Italy;5. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;1. College of Food Science, Heilongjiang Bayi Agricultural University, 2 Xinyang Road, Daqing, Heilongjiang 163319, China;2. Department of Marine Food Science and Technology, Gangneung-Wonju National University, 120 Gangneung Daehangno, Gangneung, Gangwon 210-702, South Korea;3. Guelph Research and Development Centre, Agriculture and Agri-Food Canada, 93 Stone Road W., Guelph, Ontario N1G 5C9, Canada;1. School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, China;2. Hebei Provincial Key Laboratory of Inorganic Nonmetallic Materials, College of Materials Science and Engineering, Hebei United University, Tangshan 063009, Hebei, China;3. School of Mechanical and Electrical Engineering, East China Jiaotong University, Nanchang 330013, China;1. Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan, ROC;2. National Synchrotron Radiation Research Center, Hsinchu 30076, Taiwan, ROC;3. Biomaterials Section, Department of Raw Materials and Yarns, Taiwan Textile Research Institute, New Taipei City 23674, Taiwan, ROC;1. Graduate Institute of Electro-Optical Engineering and Department of Electronic and Computer Engineering, National Taiwan University of Science and Technology, Taipei 106, Taiwan, R.O.C.;2. Taiwan Building Technology Center, National Taiwan University of Science and Technology, Taipei, Taiwan;3. Department of Materials Science Engineering, National Taiwan University of Science and Technology, Taipei 106, Taiwan, R.O.C. |
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| Abstract: | Gene delivery is a promising technique that involves in vitro or in vivo introduction of exogenous genes into cells for experimental and therapeutic purposes. Successful gene delivery depends on the development of effective and safe delivery vectors. Two main delivery systems, viral and non-viral gene carriers, are currently deployed for gene therapy. While most current gene therapy clinical trials are based on viral approaches, non-viral gene medicines have also emerged as potentially safe and effective for the treatment of a wide variety of genetic and acquired diseases. Non-viral technologies consist of plasmid-based expression systems containing a gene associated with the synthetic gene delivery vector. Polysaccharides compile a large family of heterogenic sequences of monomers with various applications and several advantages as gene delivery agents. This chapter, compiles the recent progress in polysaccharide based gene delivery, it also provides an overview and recent developments of polysaccharide employed for in vitro and in vivo delivery of therapeutically important nucleotides, e.g. plasmid DNA and small interfering RNA. |
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