巨噬细胞清道夫受体单核苷酸多态性与前列腺癌易感及患者预后的相关性分析

目的探讨分析巨噬细胞清道夫受体(MSR1)单核苷酸多态性与前列腺癌易感及患者治疗预后的相关性。方法选择2017年3月至2019年5月在本院治疗的前列腺癌患者103例设为前列腺癌组,再选取同期在本院健康体检的男性受试者97例设为对照组。检测两组受试者MSRI基因r918位点及rs1904577位点的基因多态性分布情况,并分析前列腺癌化疗相关因素及MSRI基因rs918.rs1904577位点与前列腺癌患者生存预后的关系。结果两组受试者MISRI基因rs918位点基因型GG、AG.AA比较,差异具有统计学意义(P<0.05),携带AG、AA基因型者相对于携带GG基因型者罹患前列腺癌的OR值分别为1.364.7.941;两组受试者MSRI基因rs1904577位点基因型GG,AG.AA比较,差异具有统计学意义(P<0.05),携带AG、AA基因型者相对于携带GG基因型者罹患前列腺癌的OR值分别为1.819.8.228。对可能影响患者化疗疗效的各因素进行单因素及多因素logstie回归分析,其中T分期.CGleason评分以及MSRI基因rs1904577位点基因型进人回归模型(P<0.05),是影响患者化疗疗效的重要因素。MSR1基因rs918位点CG以及AG+AA基因型前列腺癌患者生存情况比较,差异无统计学意义(P>0.05)。MSRI基因rs1904577位点GG基因型前列腺癌患者生存情况显著优于AG+AA基因型患者(P<0.05)。结论MSR1基因ns918位点和rs1904577位点单核苷酸多态性与前列腺癌易感性相关,其中rs1904577位点单核苷酸多态性与患者化疗的疗效及生存预后有关。

Correlation analysis of MSR1 single nucleotide polymorphism with prostate cancer susceptibility and prognosis

Objective To investigate the relationship between MSRI single mucleotide poly-morphism and prostate cancer susceptibility and prognosis.Methods From March 2017 to May 2019,103 patients with prostale cancer treated in our hospital were selected,and 97 male subjects in our hospital during the same period were selected as the control group.'The rs918 and rs 1904577 poly-morphisms of MSRI gene were detected in the Iwo groups,and the relationship between chemnotherapy related factors of prostate cancer and rs918 and rs1904577 locus of MSRI gene and survival and prog-nosis of prostate cancer patients were analyzed.Results The comparison of genotypes GG,AC and AA at rs918 locus of MSRI gene between the two groups showed statistically signifieant differences(P<0.05).The OR values of patients with AG and AA genotypes were 1.364 and 7.941 compared with those with CG genotypes for prostate cancer.The genotypes GC,AG and AA of MSRI gene rs1904577 were compared between the two groups,and the differences were statistically signifcant(P<0.05).The OR values of those with AG and AA genotypes were 1.19 and 8.228,repectively,compared with those with CG genotypes.Univariate and multivariate logistic regression anaysis was used to analyze the factors that may afet the fficacy of chenotherapy.T slage,Gleason score and rs1904577 genotype of MSRI gene entered the regression model(P<0.05).There was no signifcant difference in survival between GG and AG+AA genolypes(P>0.05).The survival rate of patients with MSRI rs1904577 GG genotype was significantly better than that of AG+AA genotype(P<0.05).Conclusions r918 and rs1904577 single nucleotide polymorphisms of MSRI gene are relat-ed to the sucepibility of prostate cancer,and rs1904577 single nucletide polymorphisms are related to chemotherapy effect and survival prognosis of patients.