泮托拉唑联合凝血酶对上消化道出血治疗效果及对凝血功能指标的影响

目的:观察泮托拉唑联合凝血酶对上消化道出血患者临床效果及凝血功能指标的影响.方法:选择2019年1月至2020年10月驻马店市中心医院收治的上消化道出血患者86例,按随机数字表法分为两组,各43例.在常规治疗基础上,对照组给予泮托拉唑治疗,观察组给予泮托拉唑联合凝血酶治疗,共治疗7?d.比较两组临床疗效、凝血功能指标、...

Effect of Pantoprazole Combined with Thrombin on Upper Gastrointestinal Bleeding and Coagulation Function

Objective:To observe the clinical effect of pantoprazole combined with thrombin on patients with upper gastrointestinal bleeding and the influence of coagulation function.Methods:86 patients with upper gastrointestinal bleeding in Zhumadian Central Hospital from January 2019 to October 2020 were selected and randomly divided into two groups,43 cases in each group.On the basis of conventional treatment,the control group was treated with pantoprazole,and the observation group was treated with pantoprazole combined with thrombin for 7 days.The clinical efficacy,coagulation function,hemostasis time,blood transfusion volume and adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.67%,higher than 81.40%of the control group,the difference was statistically significant(P<0.05).TT,APTT and Pt of the two groups after treatment were shorter than before treatment,and TT(17.49±1.20)s,APTT(34.15±2.89)s and PT(12.03±0.84)s of the observation group were shorter than those of the control group(P<0.05).The observation group hemostasis time(29.83±3.66)h,shorter than the control group,blood transfusion volume(523.26±31.53)ml,less than the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Pantoprazole combined with thrombin in the treatment of patients with upper gastrointestinal tract can effectively shorten TT,APTT,PT and hemostasis time,reduce the amount of blood transfusion,clinical treatment is safe and effective.