氧化应激在衰弱发病机制中的作用

衰弱包括躯体衰弱、认知衰弱与社会心理衰弱,衰弱老年人表现为多个器官和系统生理储备功能下降,当遇到微小的刺激如呼吸道感染、微创手术等,便可引发慢病加剧、再住院、跌倒、谵妄、失智、失能,甚至死亡等一系列不良事件。衰弱的本质是动态的,个体从健康、衰弱前、衰弱再到失能是一种连续演变的过程,经过早期干预,衰弱可在一定程度上逆转,从而减少生理储备的损失。因此,研究衰弱的发病机制,明确与衰弱相关的生物标志物并尽早识别非常重要。氧化应激在衰弱的发病机制中起了重要作用,本文对氧化应激在衰弱发生中的作用进行探讨,重点论述氧化应激标志物、抗氧化防御系统及氧化应激相关线粒体功能障碍与衰弱的关系。

The role of oxidative stress in the pathogenesis of frailty

Frailty includes physical, cognitive, socio-psychological decline. Frailty of the elderly manifested the reduction of phy-siological functions of multiple organs and/or systems. When exposed to minor stimuli such as respiratory infection or minimal invasive surgery, a series of adverse events such as exacerbation of chronic disease, re-hospitalization, fall, delirium, dementia, disability, and even death can be caused. Frailty is dynamic in nature, which is a continuous evolution process from health, pre-frail, frail to disability and can be reversed to some extent with early interventions, thus reducing the loss of physiological reserves. Therefore, it is important to investigate the pathogenesis of frailty and identify associating biomarkers as soon as possible. Oxidative stress (OS) plays a crucial role in the pathogenesis of frailty. This paper intends to review and discuss the role of oxidative stress in the occurrence of frailty, focusing on its relationship with oxidative stress markers, antioxidant defense system, and oxidative stress-related mitochondrial dysfunction.