DLG1在膀胱癌中的表达及其与临床病理特征和预后的关系

目的 探讨DLG1在膀胱癌中的表达及其与临床病理特征和预后的关系.方法选取2009年2月至2014年9月在本院收治的膀胱癌患者138例,采用实时荧光逆转录法及免疫组化法测定DLG1在膀胱癌组织和正常膀胱组织中的表达水平,分析其与临床病理参数和预后的关系.结果 膀胱癌组织中DLG1 mRNA和DLG1蛋白表达水平高于正常...

Expression of DLG1 in bladder cancer and its relationship with clinicopathological features and prognosis

Objective To investigate the expression of DLG1 in bladder cancer and its rela-tionship with clinicopathological features and prognosis.Methods The expression levels of DLGI in the bladder eancer tissues and normal bladder tissues collected from 138 cases of bladder cancer pa-tients from February 2009 to September 2014 were detected by real-timne fluorescence reverse transcrip-tion and immunohistochemistry,and its correlation with elinicopathological features and prognosis was analyzed.Results The mRNA and protein expression levels of DLGI of bladder cancer group was higher than that in normal bladder group(P<0.01).The positive rate of DLC1 protein expression in bladder cancer was higher than that in normal bladder group(P<0.01).The expression level of DLGI protein was not significantly correlated with age(P>0.05),while was positively correlated with TMN stage,pathological grade,recurrence,depth of invasion,vascular infiltration,maximal diameter of tumor(≥2 cm)and lymph node metastasis(P<0.01).The 3-year survival rate and survival time of the DLGI negative group were significantly higher than those of the DLG1 positive group(P<0.01).Conclusions The expression of DLG1 is elevated in bladder cancer patients,and it can pro-mote the disease development,so patients with low expression of DLCI can obtain a better prognosis.