| Effect of Calcium Ionophore and Calcium Channel Blockers on Immediate Hypersensitivity Reactions |
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| 引用本文： | 黄钦田,陈丙莺,孙爱民.Effect of Calcium Ionophore and Calcium Channel Blockers on Immediate Hypersensitivity Reactions[J].南京医科大学学报(英文版),1994(1). |
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| 作者姓名： | 黄钦田 陈丙莺 孙爱民 |
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| 作者单位： | Department of Biochemistry，Nanjing Medical University，Nanjing 210029，P.R.China |
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| 摘 要： | ＥｆｆｅｃｔｏｆＣａｌｃｉｕｍＩｏｎｏｐｈｏｒｅａｎｄＣａｌｃｉｕｍＣｈａｎｎｅｌＢｌｏｃｋｅｒｓｏｎＩｍｍｅｄｉａｔｅＨｙｐｅｒｓｅｎｓｉｔｉｖｉｔｙＲｅａｃｔｉｏｎｓＨｕａｎｇＱｉｎｔｉａｎ（黄钦田）ＣｈｅｎＢｉｎｇｙｉｎｇ（陈丙莺）ＳｕｎＡｉｍ...
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Effect of Calcium Ionophore and Calcium Channel Blockers on Immediate Hypersensitivity Reactions |
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| Huang Qintian,Chen Bingying,Sun Aimin.Effect of Calcium Ionophore and Calcium Channel Blockers on Immediate Hypersensitivity Reactions[J].Journal of Nanjing Medical University,1994(1). |
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| Authors: | Huang Qintian Chen Bingying Sun Aimin |
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| Abstract: | The release of mediators from mast cells is a model for cell secretion and is an in-vitro index for immediate hypersensitivity reactions. Calcium influx is generally accepted to be the primary biochemicalevent in mast cell activation.We studied the effect of the calcium ionophore A 23187 and calcium channelblockers,nifedipine and verapamil, in triggering the activation of rat peritoneal mast cells.At suitableconcentration nifedipine and verapamil have had the inhibition effect in the IgE-dependent roaction. |
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| Keywords: | calcium ionophore A23187 calcium channel blocker nifedipine verapamil mediator Histamine |
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