乳腺癌446例临床病理分析

目的了解蚌埠地区乳腺癌的发病情况并分析其临床病理特点.方法回顾性分析446例乳腺癌病例的临床特点、肿瘤大小、病理分级、淋巴结转移、pTNM分期及部分病例雌、孕激素受体（ER、PR）、癌基因C-erbB-2表达情况.结果 446例中女性占99.6%,平均年龄49.76岁,均以乳腺肿块为首发症状.自发现肿块至病理确诊平均时间11.58个月.肿瘤长径平均3.06 cm.浸润性导管癌占92.8%,转移率58.8%,胸小肌外组和后组淋巴结转移率较高.ER阳性率45.3%,PR阳性率44.2%,C-erbB-2阳性率81.4%,C-erbB-2蛋白表达与ER、PR表达均有相关性.结论该地区乳腺癌多见于中老年妇女,早期发现率较低,就诊时均为浸润性癌,且半数已发生转移.开展乳腺癌普查对乳腺癌防治具有重要意义.

Clinicopathological analysis of 446 cases of breast cancer

Objective To understand the incidence and the clinicopathological characteristics of breast cancer in Bengbu area. Methods The clinicopathological datas of 446 cases of breast cancer were analyzed retrospectively, which included the clinical profile, tumor size, pathological grading, lymphatic metastasis, pTNM staging, hormonal receptor status and oncogene C-erbB-2 protein expression of some cases. Results Female was found in 99.6 % of the patients. The average age was 49.76 years old. Most patients presented firstly by breast masses. The average time was 11.58 months from discovering the mass to final pathological diagnosis. The average longest diameter was 3.06cm. Invasive ductal carcinoma was found in 92.8 %. Metastasis was found in 58.8 %. Lymphatic metastasis rate was higher in extrinstic and posterior pectoralis monor. ER expression rate was 45.3 % and PR, 44.2 %. The positive rate of C-erbB-2 was 81.4 %. C-erbB-2 protein expression was found to be related to the status of ER and PR. Conclusion Breast cancer is nrore commonly found in middle and old women. Early discovery rate is lower and invasive carcinoma is diagnosed in most cases while metastasis iS found in hslof the cases. Carrying out breast cancer census is of important significance for prevention and treatment of breast cancer.