米非司酮在诊断性刮宫术后治疗更年期功能失调性子宫出血的临床疗效分析

目的：通过观察米非司酮治疗诊断性刮宫术后更年期功能失调性子宫出血的情况，分析探讨其临床疗效。方法：将入组患者分为观察组和对照组，观察组诊断性刮宫术后采用米非司酮治疗，对照组只采用诊断性刮宫治疗。通过监测激素FSH、LH、PRL、E2水平、HGB值、子宫B超检查、月经变化情况及随访期间观察出现副反应与复发情况评价两种方法疗效。结果：观察组治疗后同治疗前相比：FSH水平有显著性差异，P〈0．05；E2水平有极显著性差异，P〈0．01；子宫内膜厚度及HGB值变化均有极显著性差异，P〈0．01。治疗后两组相比：子宫内膜厚度及HGB值均有显著性差异，P〈0．05；进入绝经期者有极显著性差异，P〈0．01；恢复正常月经及月经过多或经期长者均有显著性差异，P〈0．05；随访期间两组在出现复发上有显著性差异，P〈0．05；出现肝肾功损害上无显著性差异，P〉0．05。结论：米非司酮治疗诊断性刮宫术后更年期功能失调性子宫出血疗效佳、副反应轻、复发率低，是一种理想的治疗药物。

The Clinical Analysis of Mifepristone Treatment in Dysfunctional Uterine Bleeding Menopause after Diagnostic Curettage

Objective： By observing the diagnostic curettage mifepristone treatment of dysfunctional uterine bleeding after menopause, the analysis of its clinical efficacy. Method： Patients were divided into observation group and control group, then observation group after diagnostic curettage treated with mifepristone, the control group treated only with diagnostic curettage. By monitoring the hormone FSH, LH, PRL, E2 levels, HGB value, uterine B-ultrasound, menstrual changes, and adverse reactions occurred during follow-up observation and evaluation of recurrence, efficacy of two methods. Result： FSH levels were significantly dif- ferent before and after treatment, P 〈0.05; E2 levels were significantly different, P 〈0.01; endometrial thickness and changes in HGB values were highly significant differences, P 〈 0.01. Compared two groups after treatment： Endometrial thickness and HGB values were significantly different, P 〈0.05; into menopause who have a very significant difference, P 〈0.01; resume normal menstruation and menorrhagia or menstrual elderly persons. There was a significant difference, P 〈0.05 ; recurrence during follow-up on the two groups were significantly different, P 〈0.05 ; there was no damage to liver and kidney function significantly different, P〉 0.05. Conclusion： Curettage after mifepristone treatment and diagnosis of dysfunctional uterine bleeding menopause good efficacy, side effects light, low recurrence rate, is an ideal treatment.