| 薏苡仁提取物的镇痛活性部位筛选 |
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| 引用本文： | 吴月国,张萍,赵铮蓉,刘骅,郑高利.薏苡仁提取物的镇痛活性部位筛选[J].中国现代应用药学,2012,29(6):503-506. |
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| 作者姓名： | 吴月国 张萍 赵铮蓉 刘骅 郑高利 |
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| 作者单位： | 浙江省医学科学院,浙江省医学科学院,浙江省医学科学院,浙江省医学科学院,浙江省医学科学院 |
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| 基金项目： | 浙江省中医药管理局青年项目（2008YB005） |
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| 摘 要： | 目的筛选薏苡仁提取物镇痛的活性部位。方法采用小鼠热板法、甩尾法和醋酸扭体法评价薏苡仁醇提物的4个不同极性部位的镇痛作用,筛选其镇痛有效部位。结果薏苡仁提取物的4个不同极性部位均有不同程度地镇痛作用,其中以石油醚部位和乙酸乙酯部位效果显著。结论薏苡仁提取物具有镇痛作用,其活性成分主要在石油醚和乙酸乙酯部位。
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| 关 键 词： | 薏苡仁 镇痛 热板法 热水甩尾法 醋酸扭体法 |
| 收稿时间： | 9/7/2011 1:32:21 PM |
| 修稿时间： | 4/6/2012 12:12:08 PM |
Screening of Antalgic Fractions of Coicis Semen |
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| WU Yueguo,ZHANG Ping,ZHAO Zhengrong,LIU Hu,ZHENG Gaoli.Screening of Antalgic Fractions of Coicis Semen[J].The Chinese Journal of Modern Applied Pharmacy,2012,29(6):503-506. |
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| Authors: | WU Yueguo ZHANG Ping ZHAO Zhengrong LIU Hu ZHENG Gaoli |
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| Institution: | Zhejiang Academy of Medical Sciences,Zhejiang Academy of Medical Sciences,Zhejiang Academy of Medical Sciences,Zhejiang Academy of Medical Sciences,Zhejiang Academy of Medical Sciences |
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| Abstract: | OBJECTIVE To screen the antalgic fractions of Coicis Semen. METHODS The antalgic effect was observed by mice hot-plate test, mice tail-immersion test and mice writhing test, being given the four fractions from ethanol extract of Coicis Semen Decoction via the gastric perfusion. RESULTS The four fractions had antalgic effect, among which the petroleum ether fraction and ethyl acetate fraction were more effective. CONCLUSION Coicis Semen Decoction has antalgic effect. The active parts are in petroleum ether fraction and ethyl acetate fraction. |
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| Keywords: | Coicis Semen antalgic hot-plate test tail-immersion test writhing test |
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