乳酸杆菌对ApoE-/-小鼠动脉粥样斑块形成抑制作用

目的 研究乳酸杆菌对载脂蛋白E(apoE)基因缺陷小鼠动脉粥样斑块形成的影响,探讨乳酸杆菌抗动脉粥样硬化作用机制。方法 将apoE基因缺陷(ApoE^-/-)小鼠随机分为4组:对照组(A组)、乳酸杆菌10⁸组(B组)、乳酸杆菌10¹⁰组(C组)、乳酸杆菌10¹²(D组)。A组喂养正常小鼠饲料(AIN-93),B、C、D组在正常饲料基础上添加10⁸,10¹⁰,10¹²cfu/mL乳酸杆菌喂养16周,检测动脉粥样斑块面积。结果 乳酸杆菌10¹²,10¹⁰,10⁸cfu/mL组的主动脉窦动脉粥样斑块面积分别为13.98%,17.36%,21.54%,比对照组的30.51%分别低54.18%,43.10%,29.40%,差异有统计学意义(P<0.05);随着乳酸杆菌浓度增加,主动脉窦动脉粥样斑块面积减少,但乳酸杆菌各组之间动脉粥样斑块面积差异无统计学意义。结论 乳酸杆菌可以抑制ApoE^-/-小鼠动脉粥样斑块形成,具有抗动脉粥样硬化作用。

Loctobacillus casei inhibits atherosclerotic plaque formation in apoE-deficient mice

Objective To explore the effect of Lctobacillus casei on atheroscleroticplaque founation in apoE-deficient mice and its mechanismin anti-atherogenelsis.Methods After 16 weeks intervention with Lctobacillus casei,atherosclerotic plaque area in aortic sinus was assessed with in age analysis.Results The plaque area in aortic sinus in mice fed with Lctobacillus casei diet was less than that of positive group.Conclusion The result suggests that Lctobacillus casei has the capacity of inhibiting atherosclerotic plaque founation and progression in apoE-deficient mice.