全身骨密度及骨矿含量与体质量指数的关系：287例汉族健康志愿者调查*★

背景：骨密度及骨矿物含量是诊断骨质疏松及评价骨质量的重要指标，肥胖是否影响骨质疏松的发生尚无定论。目的：调查分析287例汉族健康志愿者全身骨密度、骨矿物含量与肥胖的关系。设计、时间及地点：调查分析，于2006-01/12在济南市妇幼保健院完成。对象：选择健康志愿者287人，年龄（37±17）岁。方法：测量287例汉族健康志愿者的身高、体质量、全身各部位的骨密度及骨矿物含量。以体质量指数对样本进行分组：体质量指数≥28 kg/m2为肥胖；体质量指数 ≥24 kg/m2，< 28 kg/m2为超重；体质量指数≥ 18.5 kg/m2，< 24 kg/m2为正常体质量。主要观察指标：采用协方差分析比较不同体质量指数调查对象的骨密度及骨矿物含量；采用偏相关分析法分析体质量指数与全身各部位骨密度及骨矿物含量的关系。结果：协方差分析显示，在排除性别和年龄的影响后，肥胖组全身、头部、上肢、下肢、躯干、脊柱部位的骨密度及骨矿物含量均高于超重组和正常体质量组（P < 0.05~0.01）。偏相关分析显示，在排除性别和年龄的影响后，体质量指数与全身总骨密度、全身总矿物含量、头骨密度、头骨矿物含量、上肢密度、上肢矿物含量、下肢密度、下肢矿物含量、躯干密度、躯干矿物含量、脊柱密度、脊柱矿物含量均呈显著正相关（P均=0.000）。结论：全身骨密度及骨矿物含量与肥胖呈正相关。

Correlation among bone density, bone mineral content and body mass index: An investigation of 287 Chinese Han volunteers

BACKGROUND: Bone density (BMD), bone mineral content (BMC) are important indexs to assess osteoporosis and bone quality. It remains unclear if obesity can result in osteoporosis.OBJECTIVE: To investigate the relationship among BMD, BMC, body mass index (BMI) and obesity in 287 Chinese Han people.DESIGN, TIME AND SETTING: The investigation and analysis was performed at Jinan Maternity and Child Care Hospital from January to December of 2006.PARTICIPANTS: 287 healthy volunteers aged (37±17) years were adopt in the study.METHODS: Body weight, height, BMC and BMD of all subjects were measured. 287 volunteers were divided into 3 groups according to body mass index. Obesity was defined as BMI greater than or equal to 28 kg/m2, overweight was defined as BMI greater than or equal to 24 kg/m2 and lower than 28 kg/m2, the normal weight was defined as BMI greater than or equal to 18.5 kg/m2 and lower than 24 kg/m2. MAIN OUTCOME MEASURES: Analysis of covariance was used to compare the BMC and BMD, and co-related factor analysis among BMC, BMD and BMI was analyzed with partial correlation analysis. RESULTS: Analysis of covariance showed that, after controlling for gender and age, correlation coefficients of BMD and BMC in all over the body, head, upper limb, lower limb, trunk and spine were greater than that in the normal weight group (P < 0.05-0.01). Partial analysis showed that there were significant positive correlation between BMD and BMC in all over the body, head, upper limb, lower limb, trunk and spine (all P=0.000) .CONCLUSION: There was a positive correlation between bone mass and obesity.