Defective Calcium-Dependent Signal Transduction in T Lymphocytes of Ataxia-Telangiectasia |
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Authors: | N. KONDO R. INOUE S. NISHIMURA K. KASAHARA T. KAMEYAMA Y. MIWA P. R. LORENZO I T. ORII |
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Affiliation: | Department of Pediatrics, Gifu University School of Medicine, Gifu, Japan |
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Abstract: | T-cell functions of two patients with ataxia-telangiectasia were investigated. Patients with ataxia-telangiectasia had reduced percentages of circulating CD3+ cells and CD4+ cells, although neither patient had a reduced percentage of circulating CD8+ cells. The proliferative responses and interleukin-2 production of peripheral blood mononuclear cells to T-cell mitogens were reduced in the patients. The intracellular calcium concentration in T cells or CD4+ cells from both patients was only slightly increased after phytohaemagglutinin stimulation. Moreover, the concentration after OKT3 stimulation was not or only slightly increased in T cells or CD4+ cells from both patients. Our results suggest that the functional defect of T cells is caused by defective Ca2+-dependent signal transduction through the CD3 complex of the surface in T cells of ataxia-telangiectasia. |
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