Studies on the adsorption and solubility of nalidixic acid |
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| Institution: | 1. Key Laboratory of Freshwater Fishery Germplasm Resources, Ministry of Agriculture, Shanghai Ocean University, Shanghai 201306, China;2. Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Stigbøjlen 4, DK-1870 Frederiksberg C, Denmark;3. Ningbo Academy of Inspection and Quarantine of the P.R. China, Ningbo 315012, China;4. Departement of Food Science, University of Liège – FARAH-Veterinary Public Health, Quartier Vallée 2, Avenue de Cureghem 10, Sart Tilman B43bis, 4000 Liège, Belgium;5. College of Food Science and Technology, Shanghai Engineering Research Centre of Aquatic-Product Processing & Preservation, Shanghai Ocean University, Shanghai 201306, China;1. Department of Pharmacology and Biomedical Sciences, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan;2. The Jordanian Pharmaceutical Manufacturing Company PLC (JPM), Naor, Jordan;3. College of Pharmacy, Al Ain University of Science and Technology, Al Ain, United Arab Emirates |
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| Abstract: | The adsorption of nalidixic acid on certain pharmaceutical additives was investigated and its extent estimated. Also, the effects of various surface-active agents and hydrophilic polymers on the solubility of the drug was determined. The adsorption isotherms have revealed that the degree of adsorption increased in the order; microcrystalline cellulose < ethyl cellulose < silicon dioxide < aluminium magnesium silicate. Studies on the solubility of nalidixic acid at 37°C using different concentrations of hydrophilic polymers have demonstrated that methyl cellulose, polvinylpyrrolidone and polyethylene glycol 6000 have comparable effects. Polyvinyl alcohol caused only a marginal increase in solubility. The surface-active agents, sodium lauryl sulphate and polysorbate 80, also increased solubility of the drug. The values of the heat of solution and the free energy changes were calculated from the Van't Hoff plots. The values of heat of solution for all systems were comparable, but the free energy changes indicate that sodium lauryl sulphate causes the most marked effect on solubility. |
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