基于CiteSpace和VOSviewer的白芍研究现状及研究热点可视化分析

目的 基于CiteSpace和VOSviewer文献计量学方法，分析白芍研究现状并预测未来的研究热点和发展趋势。方法 分别从中国知网数据库、万方数据库、Web of Science数据库核心集中收集白芍研究文献，导入NoteExpress中删除重复文献、不合格文献并统一关键词，再利用Excel、CiteSpace、VOSviewer软件分别对中英文文献的发文量、发文期刊、发文作者、发文机构、发文国家、文献被引频次、关键词等进行可视化分析。结果 共检索到符合要求的文献4 046篇，其中中文文献3 334篇，英文文献712篇。白芍研究相关的年发文量整体呈上升趋势，中英文发文量最多的机构分别为北京中医药大学（76篇）和扬州大学（73篇），发文量最多的作者分别为魏伟（24篇）、Tao Jun（66篇）。开展白芍研究的国家主要以中国为主，刊载量最多的中英文期刊分别是《中草药》和Journal of Ethnopharmacology。被引频次前10的中英文文献主要为白芍药理作用及其机制研究方向，包括抗炎、抗氧化、抗抑郁、镇痛等方面。结论 白芍研究热点集中在数据挖掘、组方规律以及白芍及其药效成分的药理作用和作用机制方面，尤其在抗氧化、抗炎、神经保护、抗抑郁、调节肠道菌群等方面的作用机制的深入研究可能是未来主要的研究趋势。

Visualization analysis of research status and hotspots of Paeoniae Radix Alba based on CiteSpace and VOSviewer

Objective To analyze the research status and predict future research hotspots and development trends of Baishao (Paeoniae Radix Alba) based on CiteSpace and VOSviewer bibliometric methods. Methods The relevant articles of Paeoniae Radix Alba were retrieved from the CNKI, Wanfang Data, and Web of Science databases, and importing them into NoteExpress to remove duplicate literature and unqualified literature, and unify keywords. The Excel, CiteSpace, and VOSviewer software were used to visually analyze the publication volume, publication journal, publication author, publication institution, publication country, citation frequency, and keywords of Chinese and English literature. Results A total of 4 046 qualified literature were retrieved, including 3 334 Chinese literature and 712 English literature. The overall annual publication volume of Paeoniae Radix Alba showed an upward trend. The institutions with the highest number of publications were Beijing University of Chinese Medicine (76 articles) and Yangzhou University (73 articles), respectively. The authors with the highest number of publications were Wei Wei (24 articles) and Tao Jun (66 articles). The main countries conducting research on Paeoniae Radix Alba were China, and the most widely published Chinese and English journals were Chinese Traditional and Herbal Drugs and Journal of Ethnopharmacology. The top 10 cited Chinese and English literature mainly focued on the research direction of the pharmacological effects and mechanisms of Paeoniae Radix Alba, including anti-inflammatory, antioxidant, antidepressant, analgesic, and other. Conclusion The research hotspots of Paeoniae Radix Alba are focused on data mining, formula formation rules, pharmacological effects and mechanisms of Paeoniae Radix Alba and its pharmacological components, especially in the anti-oxidation, anti-inflammation, neuroprotection, anti-depression, regulation of intestinal flora and other aspects of the mechanism of the main research trends in the future.