缺血性脑血管病患者LPA和AP水平变化的临床研究

目的观察缺血性脑血管病患者血浆溶血磷脂类分子（LPA和AP）的变化，探讨其在缺血性脑血管病发生发展以及早期诊断中的临床意义。方法对68例脑梗死患者（包括进展型脑梗死患者32例，稳定型脑梗死患者36例）和28例短暂性脑缺血发作（TIA）患者，在发病后3d内测定血浆LPA、AP水平，并与30例体检健康者作对照。结果脑梗死和TIA两组患者血浆LPA、AP水平均显著高于对照组，差异有统计学意义（P〈0．01）；进展型脑梗死患者组血浆LPA、AP水平较稳定型脑梗死组患者明显增高，差异有统计学意义（P〈0．01）。结论LPA、AP参与了缺血性脑血管疾病发生、发展的病理生理过程，其增高程度与患者病情密切相关。溶血磷脂类分子可作为缺血性脑血管疾病的预警因子，对脑血管病的防治具有重要的临床应用价值。

Clinical Observation on the changes of levels of plasma lysophospholipids in patients with ischemic cerebrovascular disease

Objectives To determine the levels of plasma lysophatisic acid (LPA) and acidic phospholipid (AP) in patients with ischemic cerebrovascular and explore its clinical significance. Methods The levels of plasma LPA and AP in 68 cerebral infarction patients including 32 progressive cerebral infarction patients and 36 stable infarction patients were analyzed and compared with 28 patients with transient ischemic attacks (TIA) and 30 healthy control. Results The levels of LPA and AP of ischemic cerebrovascular patients were significantly higher than those of heath group (P<0.01),and the levels of patients with progressive cerebral infarction increased higherly than those of stable group (P<0.01). Conclusions The levels of LPA and AP were related to the formation and progress of the diseases. They could be a prognostic factor and clinically valuable for treating ischemic cerebrovascular disease.