| Surgical trauma and postoperative nutrition:A longitudinal study of muscle protein metabolism |
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| 作者姓名： | Erik Vinnars Professor |
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| 作者单位： | Department of Anaesthesiology and the Metabolic Research Laboratory，Karolinska Institute，St Gorans Hospia al，S-112 81 Stockholm，Sweden，Department of Anaesthesiology and the Metabolic Research Laboratory，Karolinska Institute，St Gorans Hospia al，S-112 81 Stockholm，Sweden |
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| 摘 要： | A catabolic state develops following surgical trau-ma.including weight loss and muscle wasting,whichleads to an increased loss of nitrogen in the urineThere is a decrease in muscle protein synthesis and anincreased translocation of amino acids from muscle tothe splanchnic area.This results in an impoverish-ment of muscle free amino acids.mainly GLN,andeventually impairment of muscle function which can-not be counteracted by conventional TPN.However,TPN supplemented with GLN improves nitrogen bal-
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