| 孕期肾素-血管紧张素系统构建在心血管疾病发育起源中的研究现状 |
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| 引用本文： | 高芹芹,张鹏杰,李凌君,等. 孕期肾素-血管紧张素系统构建在心血管疾病发育起源中的研究现状[J]. 中国实用妇科与产科杂志, 2014, 30(1): 31-34 |
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| 作者姓名： | 高芹芹 张鹏杰 李凌君 等 |
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| 作者单位： | 作者单位： 苏州大学附属第一医院胎儿医学研究所，江苏 苏州215006 |
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| 基金项目： | “十二·五”国家科技支撑计划（2013BAIO4BO5）；国家自然科学基金（81320108006，81030006）；江苏省卫生类创新团队；“科教兴卫工程”医学重点学科；苏州市科学技术局项目（SZS201204） |
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| 摘 要： | 近年来，越来越多的研究证实多种宫内不良环境因素（如胎儿缺氧、营养不良和糖皮质激素治疗等）均能改变孕期肾素-血管紧张素系统（RAS）的构建与功能。RAS的这些改变对子代心血管系统的功能可造成重要影响，在胎源性心血管疾病发育起源中起重要的作用。该文将对孕期RAS构建及其在心血管疾病发育起源中的近期研究发现和进展进行简要概述。
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| 关 键 词： | 孕期 肾素-血管紧张素系统 心血管疾病 发育起源 |
Renin-angiotensin system build on during pregnancy and origin and development of cardiovascular disease. |
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| GAO Qin-qin,ZHANG Peng-jie,LI Ling-jun,XU Zhi-ce.. Renin-angiotensin system build on during pregnancy and origin and development of cardiovascular disease.[J]. Chinese Journal of Practical Gynecology and Obstetrics, 2014, 30(1): 31-34 |
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| Authors: | GAO Qin-qin ZHANG Peng-jie LI Ling-jun XU Zhi-ce. |
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| Affiliation: | The First Affiliated Hospital of Soochow Medical University,Suzhou 215006,China |
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| Abstract: | Abstract：Recently, more and more studies have demonstrated that a variety of intrauterine adverse environmental factors (including hypoxia, malnutrition and glucocorticoid) could alter renin-angiotensin system (RAS) and its functions during pregnancy. Most importantly, those RAS alterations may impact on cardiovascular functions in the offspring, and play a pivotal role in the pathophysiological development of various cardiovascular diseases in utero. This article provides a brief overview of the development of RAS during pregnancy and the importance of RAS in fetal origins of cardiovascular diseases. |
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| Keywords: | pregnancy renin-angiotensin system cardiovascular diseases developmental origins |
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