| 文拉法辛缓释剂合用喹硫平治疗40例老年期抑郁症的临床分析 |
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| 引用本文： | 郝伟平. 文拉法辛缓释剂合用喹硫平治疗40例老年期抑郁症的临床分析[J]. 中国民康医学, 2011, 23(5): 535-537. DOI: 10.3969/j.issn.1672-0369.2011.05.005 |
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| 作者姓名： | 郝伟平 |
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| 作者单位： | 太原市精神病院老年科,山西,太原,030045 |
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| 摘 要： | 目的:评估文拉法辛缓释剂合用喹硫平治疗无精神病性症状的老年期抑郁症疗效和安全性。方法:将符合入组标准的无精神病性症状的老年期抑郁症患者80例,随机分配到文拉法辛缓释剂合用喹硫平治疗组(研究组)和单用文拉法辛缓释剂治疗组(对照组),在入组时(第0天)和第7、14、21、28、42天分别评定HAMD和TESS,并测量生命体征;在治疗开始前和治疗结束时各进行一次血常规、尿常规检查,血生化、心电图检查。结果:第1周末时,研究组的HAMD评分即下降了29.53%,显著高于对照组(11.83%),这种差异一直保持到研究结束,表明文拉法辛缓释剂合用喹硫平起效迅速;研究组的显效率(痊愈+显著进步)为85%,显著高于对照组(50%)(x2=16.78,P=0.001)。结论:文拉法辛缓释剂合用喹硫平治疗无精神病性症状的老年期抑郁症起效快,疗效优于单用文拉法辛缓释剂,不良反应无明显增多。
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| 关 键 词： | 文拉法辛缓释剂 喹硫平 无精神病性症状 老年期抑郁症 |
A clinical analysis of release Venlafaxine alone and combination with Quetiapine for the treatment of major senility depression |
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| HAO Wei-ping. A clinical analysis of release Venlafaxine alone and combination with Quetiapine for the treatment of major senility depression[J]. medical journal of chinese peoples health, 2011, 23(5): 535-537. DOI: 10.3969/j.issn.1672-0369.2011.05.005 |
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| Authors: | HAO Wei-ping |
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| Affiliation: | HAO Wei-ping(Old age division of Taiyuan Jingshenbing hospital,Shanxi 030045,China) |
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| Abstract: | Objective:To evaluate the efficacy and tolerability of Quetiapine combined with release Venlafaxine in the treatment of major senility depression without psychotic symptoms.Methods:80 patients were randomized to 8 weeks of Quetiapine combined release Venlafaxine or release Venlafaxine monotherapy group.HAMD and TESS were assessed on recruiting day(day 0) and day 7,14,21,28,42.Laboratory investigations were conducted.Results: Quetiapine + release Venlafaxine treatment(n=40) showed a significant greater and q... |
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| Keywords: | Release venlafaxine Quetiapine Non-psychotic major Senility depression |
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