5-Oxo-1H-3,4,5,6-tetrahydro-2,6-methano-2-benzazocin und seine Reduktionsprodukte |
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Authors: | Ulrike Ashauer-Holzgrabe |
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Abstract: | 3,4,5,6-Tetrahydro-1H-2,6-methano-2-benzazocin-5-one and its Reduction Products 3,4,5,6-Tetrahydro-1H-2,6-methano-2-benzazocin-5-one 2 has been prepared by oxidation of N-benzyl-4-piperidone 1 with cerium(IV) sulfate. 2 was reduced by sodium borohydride or lithium aluminum hydride in various solvents. The stereoselectivity of these reductions is high. The configurations of the epimeric alcohols were determined by 1H-NMR spectroscopy. |
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