| 生肌化瘀方促进创面愈合机制的网络药理学研究 |
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| 引用本文： | 鲁冰,赵堃鹏,闫语,朱玮,李福伦,李斌,向延卫. 生肌化瘀方促进创面愈合机制的网络药理学研究[J]. 上海中医药大学学报, 2021, 0(1): 102-111 |
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| 作者姓名： | 鲁冰 赵堃鹏 闫语 朱玮 李福伦 李斌 向延卫 |
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| 作者单位： | 上海中医药大学附属岳阳中西医结合医院皮肤科上海200437;上海中医药大学交叉科学研究院上海201203;上海中医药大学上海中医健康服务协同创新中心上海201203;上海中医药大学康复医学院上海201203;上海中医药大学附属岳阳中西医结合医院皮肤科上海200437;上海中医药大学康复医学院上海201203 |
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| 基金项目： | 国家自然科学基金资助项目(81673866)；国家重点研发计划“中医药现代化研究”重点专项(2018YFC1705300) |
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| 摘 要： | 目的:探究生肌化瘀方治疗慢性皮肤溃疡的作用机制.方法:利用TCMSP、TCMIP、TCMID、GeneCards、PubChem及SwissTargetPrediction数据库查找生肌化瘀方的化学成分并预测其潜在作用靶点,探索潜在作用靶点的生物学功能,利用Cytoscape软件构建"药物-化合物-靶点"多层次网络图,...
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| 关 键 词： | 生肌化瘀方 创面愈合 网络药理学 |
| 收稿时间： | 2020-10-30 |
| 修稿时间： | 2020-12-10 |
Mechanisms of Shengji Huayu Formula on promoting wound healing based on network pharmacology |
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| LU Bing,ZHAO Kunpeng,YAN Yu,ZHU Wei,LI Fulun,LI Bin,XIANG Yanwei. Mechanisms of Shengji Huayu Formula on promoting wound healing based on network pharmacology[J]. Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai, 2021, 0(1): 102-111 |
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| Authors: | LU Bing ZHAO Kunpeng YAN Yu ZHU Wei LI Fulun LI Bin XIANG Yanwei |
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| Affiliation: | Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Shanghai Innovation Center of Traditional Chinese Medicine Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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| Abstract: | Objective:To investigate the mechanisms of Shengji Huayu Formula in the treatment of chronic skin ulcer. Methods:The chemical components of Shengji Huayu Formula and its potential targets were found and predicted by TCMSP, TCMIP, TCMID, GeneCards, PubChem and SwissTargetPrediction databases. The biological functions of potential targets were explored. The multi-levels network graph of drug-compound-target was constructed by Cytoscape software, and the topological structure of the network was analyzed by cluster analysis. GO function and KEGG pathway analysis were performed for the obtained targets. Results:There were 845 compounds and 1 095 targets, which formed 2 455 component-target pairs. The GO function of Shengji Huayu Formula mainly involved metabolism, transmembrane transport, γ-aminobutyric acid signal pathway and negative regulation of inflammatory response, and KEGG pathway mainly included metabolic pathways, steroid hormone biosynthesis, nitrogen metabolism, cAMP signaling pathway, oxidative phosphorylation, insulin resistance, antibiotic biosynthesis, carbon metabolism, PPAR signaling pathway, insulin signaling pathway and so on. Conclusion:Shengji Huayu Formula may exert the therapeutic effects in treating chronic skin ulcer through multiple components and multiple targets, and Astragali Radix, Rhei Radix et Rhizoma and Draconis Sanguis play an important role. |
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| Keywords: | Shengji Huayu Formula wound healing network pharmacology |
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