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The effect of local breast radiotherapy on circulating CD34 cells |
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| Authors: | Nehad M. Alajez Wei Wang Debashis Biswas Amy Teh Robert Sutherland Melania Pintilie Mark Minden Hans Messner Anthony Fyles Mary Gospodarowicz Armand Keating Fei-Fei Liu |
| Affiliation: | aOntario Cancer Institute, Toronto, Canada;bDepartment of Medical Biophysics, University of Toronto, Canada;cDepartment of Radiation Oncology, University Health Network, Toronto, Canada;dDepartment of Radiation Oncology, University of Toronto, Canada;eAddenbrooke’s Hospital, Cambridge, UK;fDepartment of Pathology, University Health Network, Toronto, Canada;gDivision of Biostatistics, University Health Network, Toronto, Canada;hDivision of Medical Oncology and Hematology, University Health Network, Toronto, Canada |
| Abstract: | The number of circulating CD34+ (hematopoietic stem) cells (HSCs) was observed to decline by 15% in breast cancer patients after starting adjuvant radiation therapy, regardless of age or preceding chemotherapy. These data demonstrate that local radiation therapy can profoundly affect HSC homeostasis, which might have a myriad of important implications. |
| Keywords: | Hematopoietic stem cells Homing Radiation therapy Breast cancer |
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