恶性血液病183例染色体核型分析

目的探讨细胞染色体检查对恶性血液病的特点及临床意义。方法选择2006年8月至2011年5月初诊的恶性血液病患者183例,每例治疗前行骨髓涂片检查、骨髓活检、染色体核型分析。结果 183例患者中,有103例检出异常染色体核型。其中急性白血病40例,浆细胞白血病1例,淋巴瘤细胞白血病2例,慢性粒细胞白血病(CML)25例,骨髓增生异常综合征22例,多发性骨髓瘤组6例,骨髓增殖性疾病6例,再生障碍性贫血1例。与FAB亚型的关系中,75%M3有t(15;17)易位,M6有1号染色体异常,60%M2有t(8;21)易位,92%(CML)有t(9;22)易位。结论染色体核型分析是恶性血液病诊断分型的一项重要指标。

Chromosomal karyotype analysis in 183 patients with malignant hematologic diseases

Objective To investigate the characteristic and clinical significance of chromosomal karyotype analysis to malignant hematologic diseases. Methods A total of 183 patients with malignant hematologic diseases were enrolled from August 2006 to May 2011 and were subjected to bone marrow smear and bone marrow biopsy for further chromosomal karyotype analysis prior to the treatment. Results Of 183 patients enrolled, abnormal chromoso- mal karyotypes were detected in 103 cases. The diagnoses were consisted of acute leukemia （n=40）, of which plasma cell leukemia （n=1）, lymphoma cell leukemia （n=2） and chronic myelocytic leukemia （n=25） were identified; myelodysplastic syndrome （n=22）; multiple myeloma （n=6）; myeloproliferative disease （n=6） and aplastic anemia （n=l）. Based on the FAB classification,75% of patients with M3 presented t（15;17） translocation, those with M6 were associ- ated with No. 1 chromosome anomaly, 60% with M2 showed t（8;21） translocation and 92% with chronic myelocytic leukemia were shown to have t（9;22） translocation. Conclusion Chromosomal karyotype analysis is indispensible to the diagnosis and classification of malignant hematologic diseases.