胃泌素释放肽前体片段31-98检测对小细胞肺癌的临床意义

目的 与神经元特异性烯醇化酶（ＮＳＥ）对照，探讨胃泌素释放肽前体片段３１－９８（ＰｒｏＧＲＰ３１－９８）检测对小细胞肺癌（ＳＣＬＣ）的临床意义。方法 采用ＥＬＩＳＡ检测３０例ＳＣＬＣ、３０例非小细胞肺癌、１５例肺良性疾病、１５例正常健康者和１０例治疗后ＳＣＬＣ患者血液ＰｒｏＧＲＰ３１－９８和ＮＳＥ值．采用ＲＯＣ曲线确定阈值，比较诊断准确性。结果 ＳＣＬＣ组血清ＰｒｏＧＲＰ３１－９８值显著高于对照组

Clinical significance of ProGRP31 -98 in patients with small cell lung cancer

OBJECTIVE: To determine the clinical significance of serum level of pro-gastrin-releasing peptide 31-98 (ProGRP31-98) for small-cell lung cancer (SCLC) in comparison with neuron-specific enolase (NSE). METHODS: Serum level of ProGRP31-98 was measured by ELISa in 30 patients with SCLC, 30 patients with non-small-cell lung cancer (NSCLC), 10 patients with SCLC who had received treatment, 15 patients with benign lung diseases and 15 normal subjects. The receiver operating characteristic (ROC) curve was used to set the cut-off value and evaluate the diagnostic accuracy. RESULTS: The serum level of ProGRP31-98 was significantly increased in patients with SCLC as compared to that of the normal controls as well as that in any other groups of patients. It was higher in SCLC patients with extensive disease than in patients with limited disease. In patients with distant metastases, it was also higher than in those without. Increase in serum ProGRP31-98 and NSE was both seen in SCLC patients, but the former was of much greater magnitude when compared to the normal controls. Given the cut-off levels of 40 pg/ml for ProGRP31-98 and 8 micrograms/L for NSE, their sensitivity of diagnosis in SCLC was 73% and 60%, respectively. The area under ROC curve of ProGRP31-98 was significantly larger than that of NSE. Similar results of diagnostic sensitivity and area under ROC curve were observed in SCLC patients with limited disease. All patients responded to chemotherapy showed marked decrease in ProGRP31-98. CONCLUSION: ProGRP31-98 is a more specific and sensitive marker than NSE for the diagnosis of SCLC.