胃肠道肿瘤与一氧化氮关系研究进展

在肿瘤生物学中，一氧化氮(NO)具有复杂的浓度依赖效应。越来越多的证据表明，NO在胃肠道肿瘤的发生发展过程中起重要作用。NO与机体免疫反应、DNA损伤、凋亡发生有关。机体炎性反应可以诱导NO合成，参与肿瘤的发生。另外，NO可以引起肿瘤血管生成及血管扩张，从而利于肿瘤生长和转移。目前的研究结果NO在胃肠道肿瘤中的作用仍不一致，诱导型NOS在胃肠道肿瘤的表达研究尚不统一。本文对近年来NO在胃肠道肿瘤中的作用的研究进展作一综述。

Progress in the relation of NO and gastrointestinal cancer

Accumulating evidence indicates that NO pathway play a patent role in the gastrointestinal carcinogenesis. NO pathway is involved in immune responses, DNA damage, regulation of apoptosis. NO, which is generated under chronic inflammatory conditions that predispose individuals to cancer, has paradoxical effects. On the other hand, NO enhance tumor angiogenesis and to induce vasodilatation, thus accelerates tumor growth. But the role of NO in gastrointestinal cancer remains controversial, and iNOS has been reported to be up regulated and down regulated in gastrointestinal cancer. The review is based on the resent studies about the effects of NO pathway to gastrointestinal cancer.