鼻咽癌放疗近期疗效的多因素分析

目的:分析鼻咽癌放疗近期疗效的相关因素。方法:分析76例经病理证实的接受根治性放疗的鼻咽癌初治患者资料,分析其年龄、性别、原发肿瘤体积、放疗结束时残留肿瘤体积、原发肿瘤最大截面积、T分期、N分期、病理类型等因素与放疗50Gy时肿瘤退缩率(V50/V0、S50/S0)的关系。通过对原发肿瘤体积(V0)、50Gy肿瘤退缩率(V50/V0)、放疗结束时残留肿瘤体积(V70)进行均数统计分析,并对以上因素和放疗50Gy残留肿瘤体积(V50)进行多因素相关分析。结果:随T分期渐晚,肿瘤原发体积增大,T4期肿瘤退缩未达PR。肿瘤病理类型中未分化癌原发肿瘤体积最大,腺样囊性癌体积最小,但V50/V0中高分化鳞癌、腺样囊性癌未达PR,分别为(0.68、0.55),显示肿瘤病理类型与近期疗效密切相关(P=0.000),V50/V0(体积退缩率)与S50/S0(最大截面积退缩率)在反映肿瘤近期疗效时,密切相关,有很好的一致性。结论:50Gy时肿瘤退缩率是评价近期疗效的较可靠指标,可部分反映肿瘤放射敏感性。肿瘤最大体积退缩率与肿瘤最大截面积退缩率均可作为评价近期疗效的指标。

Multi-factor analysis of primary efficacy of nasopharyngeal carcinoma patients treated with radiotherapy

Objective:To analyze influential factors of nasopharyngeal carcinoma (NPC)patients treated with radiotherapy. Methods: The information of 76 NPC patients proved by pathology who received radiotherapy were analyzed retrospectively and the relationship between the regression rate of tumor delivered 50 GY (V50/V0,S50/S0) and age, sex, primary tumor volume, remain tumor volume of radiation treatment,cross section, T stage, N stage, histological type were analyzed. Results: T stage, the bigger of primary tumor volume and T4 stage patients didn' t get PR, the tumor volume in undifferentiated carcinoma was biggest but smallest in adenoid cystic carcinoma, in well-differentiated carcinoma and adenoid cystic carcinoma V50/V0 were 0.68,0.55 respectively, tumor histological type was significantly associated with primary efficacy (P=0.000). V50/V0 and S50/S0 were significantly related to primary efficacy. Conclusion: The regression rate of tumor delivered 50 GY is a good index in primary efficacy evaluation and can partly reflect sensitivity of tumor radiotherapy. Volume and section regression rate of tumor can both be indexes to evaluate tumor primary efficacy.