阴道微生态菌群与宫颈疾病相关性的研究进展

宫颈疾病包括宫颈炎症、宫颈鳞状上皮内病变及宫颈癌,近年研究发现阴道微生物菌群产生的细胞因子及局部免疫系统与宫颈疾病的发生、发展有关。正常女性的阴道微生态环境由多种微生物构成,其中乳杆菌对维持阴道微生态平衡发挥着重要作用。宫颈癌在女性恶性肿瘤中发生率位居第一,其发生与人乳头瘤病毒(HPV)持续感染密切相关,但并非所有感染HPV者均患宫颈癌,其病因为多因素综合作用。因乳杆菌变化导致的阴道疾病与HPV感染相互作用,共同参与宫颈疾病的发生、进展,系统有效的阴道微生态环境检测对及时调节阴道微生态平衡非常重要。阴道微生物菌群与宫颈疾病之间的关系成为许多学者的研究热点,综述阴道微生态与宫颈疾病发生、发展的相关性,为宫颈疾病尤其是宫颈癌的预防、治疗及预后提供理论依据。

Research Progress on the Relationship between Vaginal Microflora and Cervical Diseases

Cervical diseases include cervical inflammation,cervical squamous intraepithelial lesions and cervical cancer.In recent years,it has been found that vaginal microflora,its cytokines and local immune system are related to the occurrence and development of cervical diseases.The vaginal micro-ecological environment of normal women is composed of a variety of microorganisms,of which lactobacillus play an important role in maintaining vaginal micro-ecological balance.The incidence rate of cervical cancer ranks first in female malignant tumors,and its occurrence is closely related to persistent infection of human papilloma virus.However,not all people infected with human papilloma virus develop into cervical cancer.Cervical cancer is caused by multiple factors.Vaginal diseases caused by changes in lactobacillus interact with human papilloma virus infection,and both participate in the occurrence and progression of cervical diseases.Systematic effective vaginal micro-ecological environment testing is very important for timely regulation of vaginal micro-ecological balance.The relationship between vaginal microflora and cervical diseases has become a research hotspot of many scholars.This article explores the occurrence and development of vaginal microecology and cervical diseases,and provides a theoretical basis for the prevention treatment and prognosis of cervical diseases,especially cervical cancer.