In vivo production of thromboxane and prostacyclin in patients following total hip arthroplasty |
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Authors: | O Vesterqvist U Sch?tt O Berséus K Axelsson K Gréen |
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Institution: | Department of Clinical Chemistry and Blood Coagulation, Karolinska Hospital, Stockholm, Sweden. |
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Abstract: | The in vivo production of thromboxane and prostacyclin was studied by measurements of their major urinary metabolites in eight patients undergoing total hip arthroplasty. Specific methods based on gas chromatography-mass spectrometry were used to measure the urinary excretion of 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1 alpha. The excretion of these metabolites increased about 10-fold during the intra and immediate postoperative period and 4 days after surgery was still higher than during the preoperative period. The increased thromboxane formation reflects probable activation of platelets whereas the increased prostacyclin could be part of a vascular defense against induced thrombotic activity. These findings may have pathophysiological implications. |
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