Binding of diltiazem and verapamil to isolated rat heart mitochondria |
| |
Authors: | Prof. Dr. J. Rafael J. Patzelt |
| |
Affiliation: | (1) Present address: Institut für Biochemie I der Universität Heidelberg, Im Neuenheimer Feld 328, 6900 Heidelberg, FRG |
| |
Abstract: | Summary The occurrence of arrhythmias was studied in the calcium-paradox model in the isolated rat heart. Clear relationships were found between the duration of calcium-free perfusion and (a) the occurrence of calcium-free-induced electrophysiological changes, (b) the incidence and duration of subsequently induced calcium-repletion arrhythmias and (c) mechanical recovery at the end of the repletion period.The first signs of electrophysiological changes (i.e. decreased heart rate, T-wave amplitude and increased PQ-interval) and irreversible loss of myocardial recovery occurred during or after 60–90 s of calcium-free perfusion. The occurrence of calcium-repletion induced ventricular tachycardia parallelled this onset of irreversible cardiac injury. These results suggest that the process of calcium washout and subsequent sudden calcium overloading may play a role as a trigger in the pathogenesis of ventricular arrhythmias. |
| |
Keywords: | calcium paradox electrophysiology arrhythmias isolatedrat heart calcium overloading |
本文献已被 SpringerLink 等数据库收录! |