胰岛素样生长因子-1与老年2型糖尿病患者胰岛素抵抗相关性研究

目的探讨老年2型糖尿病患者血清胰岛素样生长因子-1（IGF-1）水平与胰岛素抵抗的相关性。方法选择38例老年2型糖尿病患者（糖尿病组）和30例健康人（对照组）,常规测身高、体重、血压、空腹血糖（FBG）、空腹胰岛素（INS）、血脂（TC、TG、LDL、HDL）;用免疫放射分析法检测血清IGF-1水平;并对所得数据进行统计学处理。结果糖尿病组IGF-1和HDL明显低于对照组,差异有统计学意义（P〈0.01）;而FBG、INS、TC、TG、LDL和IR明显高于对照组,差异有统计学意义（P〈0.01）。IGF-1与FBG、IR、TC、TG、LDL呈负相关（P〈0.001）,IR与FBG、FINS、TC、TG、LDL呈正相关（P〈0.05）。结论血清IGF-1水平可以反映糖尿病胰岛素抵抗严重程度,提高血清IGF-1水平并结合调脂治疗可以为糖尿病抵抗治疗提供新的思路。

Correlation between Insulin-like Growth Factor-1 and Insulin Resistance with Type 2 Diabetes in Elderly Patients

Objective To explore the correlation between the level of serum insulin-like growth factor-1 （ IGF-1 ） and insulin resistance （IR） with type 2 diabetes in elderly patients. Methods 38 eases of elderly patients with type 2 diabetes were selected as type 2 diabetes group, and 30 healthy persons were selected as controls. The height, weight, blood pressure, fasting blood glucose （ FBG）, fasting insulin （ INS）, blood fat （ TC, TG, LDL, HDL） were all measured conventionally. And the level of the serum IGF-1 was measured by radioimmunoassay. All the data was statistically treated. Results The serum IGF-1 level and HDL were significantly lower in type 2 diabetes group than those in control group （P 〈 0.01 ）. While the FBG, INS,TC ,TG, LDL and IR of the type 2 diabetes group were greatly higher than that of control group （P 〈0. 01 ）. IGF-1 anegative correlation with FBG,IR,TC,TG and LDL （P 〈 0. 001 ）,while IR had a positive correlation with FBG, INS, TC, TG and LDL （P 〈 0.05）. Conclusion Serum IGF-1 level can reflect the IR. Combination of improvement of serum IGF-1 and lipid-lowering therapy may be a new method to the treatment of diabetic IR.