新型冠状病毒Delta变异株感染同船海员的临床特点分析

目的 探讨新型冠状病毒Delta变异株感染同船海员的临床特点及接种疫苗的保护作用。方法 回顾分析2021年8-11月广西防城港市第一人民医院定点隔离病区收治的新型冠状病毒Delta变异株境外输入感染者5例及同船海员17例。依据是否接种疫苗分为接种疫苗组(10例)及未接种疫苗组(12例),回顾性分析两组临床资料。结果 同船22例海员中新型冠状病毒感染共14例(63.6%);其中未接种疫苗组感染比例高于接种疫苗组(P<0.05)。除外2例为无症状感染,其余12例出现发热、嗅味觉减退、咳嗽、胸闷、咳痰、乏力及全身酸痛等。未接种疫苗组发热持续时间为(7.62±2.32)天,接种疫苗组发热持续时间为(6.25±2.50)天,差异无统计学意义(P=0.368)。经治疗后未接种疫苗组核酸转阴时间为(65.75±25.81)天,而接种疫苗组为(44.00±28.32)天,差异无统计学意义(P=0.211)。结论 我国生产疫苗对新型冠状病毒Delta变异株具有一定的保护作用。同船海员新型冠状病毒Delta变异株感染患者核酸转阴时间明显延长,但接种疫苗与核酸转阴时间无相关性。

Clinical characteristics of Delta variant of SARS-CoV-2 of shipmate

Objective To explore the clinical characteristics of the B.1.617.2 (Delta) variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) of shipmates, and the protective effect of SARS-CoV-2 vaccines. Methods From August to November 2021, five imported cases of Delta variants of SARS-CoV-2 and 17 shipmates were enrolled, who all visited fixed point isolation endemic area of the First People's Hospital of Fangchenggang, and divided into the vaccinated group (n=10) and the unvaccinated group (n=12), the clinical data of the two groups were retrospectively analyzed. Results Among the 22 shipmates, there were 14 cases of SARS-CoV-2 infection, with the infection rate of 63.6%; the unvaccinated group was more common (P<0.05). Of 14 cases, 12 had clinical symptoms (fever, olfactory and taste loss, cough, chest tightness, expectoration, fatigue, and body aches) except for 2 asymptomatic SARS-CoV-2 infections. The difference was not statistically significant in fever duration between the vaccinated group and the unvaccinated group ([7.62±2.32] days vs [6.25±2.50] days, [P=0.368], respectively); the negative conversion time of SARS-CoV-2 nucleic acid in the unvaccinated group and the vaccinated group was (65.75±25.81) days and (44.00±28.32) days, respectively, and with no statistically significant difference (P=0.211). Conclusion The present data showed that domestic vaccine has a protective effect against the Delta variant of SARS-CoV-2. Both the prolonged time of negative conversion and whether or not vaccination have no correlation.