幼年特发性关节炎患儿血管内皮功能的系统评价和meta分析

目的 通过系统评价肱动脉血流介导的血管舒张(flow mediated dilation,FMD)功能与幼年特发性关节炎患儿(juvenile idiopathic arthritis,JIA)的相关性,探讨JIA患儿的血管内皮功能.方法 计算机检索Pubmed、Embase、Web of Science、The Co...

Vascular endothelial function of juvenile idiopathic arthritis in pediatric patients: A systematic review and meta-analysis

Objective To assess the correlation between brachial artery flow mediated dilatation (FMD) and juvenile idiopathic arthritis (JIA) by systematic review, and to explore vascular endothelial function in JIA children fatherly. Methods A case-control and cross-sectional studies regarding FMD and JIA children were conducted to collect via Computer retrieval of PubMed, Embase, Web of Science, The Cochrane Library, CNKI, WangFang Date, VIP databases and CBM, the retrieval time is from the establishment of database to August 2020. The literature screening, data extraction and bias risk assessment were independently conducted by two participants, meta-analysis was performed using Reviewer Manager 5.3 and Stata 16 software. Results There were 10 literature, 6 case-control studies, and 4 cross-sectional studies including 439 JIA children and 382 healthy controls (control group). The results of meta analysis verified that FMD value of JIA children was significantly lower than that of healthy children in the control group (weight mean difference WMD]=-3.51, 95%CI=-4.16, -2.85, P<0.01, respectively); the subgroup analysis showed that FMD values of JIA children with polyarticular, oligoarticular, and systemic were significantly lower than those in the control group (WMD polyarticular JIA=-3.30, 95%CI=-4.51, -2.09, P<0.01; WMD oligoarticular JIA=-2.39, 95%CI=-3.63, -1.15, P=0.0002; WMD systemic JIA=-2.02, 95%CI=-2.57, -1.48, P<0.01, respectively). Conclusion Children with JIA retain vascular endothelial dysfunction.