血清KL-6 水平检测在临床间质性肺病诊断中的研究进展

间质性肺病（interstitial lung disease,ILD）是一大类疾病,有病因繁多、发病机制复杂、诊断及治疗困难等特点。近年来,该病的发病率逐年上升。因早期症状和体征缺乏特异度,该病的诊断仍具挑战性。多项研究表明血清涎液化糖链抗原-6（krebs von den lungen-6,KL-6）与该病的发生、发展有密切关系,且具有操作简单、灵敏度及特异度高、成本低等优势,对间质性肺病诊断、预后判定及动态监测具有一定临床价值,目前国内尚无血清KL-6 用于诊断间质性肺病阈值的相关指南或专家共识,因此该文着重阐述血清KL-6 水平检测在临床间质性肺病诊断中的研究进展。

Research Progress of Serum KL-6 Levels in Clinical Interstitial Lung Disease Diagnosis

Interstitial lung disease （ILD）is one of the major diseases, which is characterized by various etiologies, complicated pathogenesis, and difficulty in diagnosis and treatment. In recent years, the incidence of the disease has been increasing year by year. The diagnosis of this disease remains challenging due to the lack of specificity of early symptoms and signs. Many studies have shown that Krebs von den Lungen 6 （KL-6）is closely related to the occurrence and development of this disease, and has the advantages of simple operation, high sensitivity and specificity, and low cost, there is no guideline or expert consensus on the use of serum KL-6 as a diagnostic threshold for ILD, therefore, this article focuses on the development of serum KL-6 detection in clinical I ILD diagnosis.